EFEK ULCEROGENIC DISPERSI PADAT IBUPROFEN-POLIVINILPIROLIDON (PVP) PADA TIKUS PUTIH JANTAN

Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of ibuprofen derivatives.

In order to reduce the ulcerogenic effect of ibuprofen, its carboxylic group has been converted into 5-membered heterocyclic rings. Various 1,3,4-oxadiazoles (3-8, 16-21), 1,2,4-triazoles (22-27), 1,3,4-thiadiazoles (28-30), and 1,2,4-triazine (9) derivatives of ibuprofen were prepared by cyclization of 2-(4-i-butylphenyl) propionic acid hydrazide (2) and N1-[2-(4-i-butylphenyl)-propionyl]-N4-a...

Co-precipitation with PVP and Agar to Improve Physicomechanical Properties of Ibuprofen

UNLABELLED Objective(s) : Ibuprofen is a problematic drug in tableting due to its viscoelastic properties. Additionally its high cohesivity results in low flowability. In this study, co-precipitation of ibuprofen with varying concentration of agar and PVP to optimize properties of Ibuprofen was carried out. MATERIALS AND METHODS Co-precipitates of ibuprofen- PVP or agar were prepared by solve...

Co-precipitation with PVP and Agar to Improve Physicomechanical Properties of Ibuprofen

Effect of extracorporeal irradiation on segmental bone autograft incorporation in Sprague-Dawley rats

Latar belakang: Autograft tulang digunakan pada operasi rekonstruksi kasus tumor tulang. Extracorporeal irradiation (ECI) pada tulang digunakan untuk membunuh sel tumor. Namun radiasi juga menimbulkan efek negatif terhadap osteoinduksi dan osteogenensis untuk inkorporasi autograft tulang. Penelitian ini bertujuan mempelajari pengaruh iradiasi dengan dosis 50-300 Gy terhadap kemampuan inkorporas...

co-precipitation with pvp and agar to improve physicomechanical properties of ibuprofen

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